Electrostatic deposition assisted preparation, characterization and evaluation of chrysin liposomes for breast cancer treatment

Chrysin (CHR), a flavone found in multiple vegetables, fruits and mushrooms has been explored so far as neurotropic, anti-inflammatory anti-cancer biomolecule. Despite the stated therapeutic potential, low solubility bioavailability limit its benefit. To circumvent these drawbacks, development of chrysin liposomes (CLPs) is reported present investigation. The CLPs were developed by electrostatic deposition assisted film hydration method using chitosan/lecithin to protect nano-lipoidal shell. Developed extensively characterized DSC, XPRD, FE-SEM, TEM, particle size, polydispersity index, zeta percent drug loading encapsulation efficiency. These further vitro dissolution, vivo bioavailability, anticancer stability study. Suitable PDI ZP implying stabilization CLPs. % DL EE was be 3.56 ± 0.13 90.5 1.49 respectively. DSC PXRD study revealed amorphous transition CHR, which may help increase dissolution profile. In pharmacokinetic demonstrated more than 5-fold relative silico molecular docking results interaction between two polymers. suggests that chitosan could encapsulate eventually enhances cytotoxicity well bioavailability.